Transient hypothyroidism favors oligodendrocyte generation providing functional remyelination in the adult mouse brain
نویسندگان
چکیده
منابع مشابه
Transient hypothyroidism favors oligodendrocyte generation providing functional remyelination in the adult mouse brain
In the adult brain, both neurons and oligodendrocytes can be generated from neural stem cells located within the Sub-Ventricular Zone (SVZ). Physiological signals regulating neuronal versus glial fate are largely unknown. Here we report that a thyroid hormone (T3)-free window, with or without a demyelinating insult, provides a favorable environment for SVZ-derived oligodendrocyte progenitor gen...
متن کاملDoublecortin in Oligodendrocyte Precursor Cells in the Adult Mouse Brain
Key Points Oligodendrocyte precursor cells express doublecortin, a microtubule-associated protein.Oligodendrocyte precursor cells express doublecortin, but at a lower level of expression than in neuronal precursor.Doublecortin is not associated with a potential immature neuronal phenotype in Oligodendrocyte precursor cells. Oligodendrocyte precursor cells (OPC) are glial cells that differentiat...
متن کاملP55: Neuroprotective and Neurogenesis Effects of Curcumin in the Adult Rat Brain Following Transient Global Ischemia
لطفاً به چکیده انگلیسی مراجعه شود.
متن کاملEffect of Transient Congenital Hypothyroidism on Oxidative Stress in Cardiac Tissue of Adult Male Rats
Introduction: Increased oxidative stress is involved in the pathology of cardiovascular disease. Transient congenital hypothyroidism (TCH) leads to a variety of heart disorders during adulthood. In this study, the effect of TCH on antioxidant and oxidant systems in the serum and left cardiac ventricle of adult male rats was investigated. Materials and Methods: TCH was induced by administrating ...
متن کاملDistribution of corticosteroid receptors in mature oligodendrocytes and oligodendrocyte progenitors of the adult mouse brain.
The expression of glucocorticoid receptors (GRs) was investigated immunohistochemically in two different lineages of oligodendrocytes, using carbonic anhydrase (CA) II and neuron glial antigen (NG) 2 as markers of mature oligodendrocytes and oligodendrocyte progenitors, respectively. We focused on the gray matter regions, including CA1, CA3 and the dentate gyrus of the hippocampus, the primary ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: eLife
سال: 2017
ISSN: 2050-084X
DOI: 10.7554/elife.29996